Injectable Vial Liquid Filling Line 100 Speed

N.K Industries, based in Ahmedabad, India, is a prominent manufacturer, supplier, and exporter of the Automatic Round Bottle Sticker Labeling Machine. Our machine represents the forefront of labeling technology, designed to deliver superior performance and efficiency in labeling a wide range of round bottles. With the integration of the latest servo-controlled label dispensing system and advanced sensing technology, our Automatic Round Bottle Sticker Labeling Machine stands out for its exceptional accuracy and reliability.

The machine incorporates a refined servo-controlled dispensing system and a sophisticated sensing system for both labels and containers. Utilizing a special background suppression sensor for container detection, it ensures precise label placement. A standout feature is the "No Change Parts" design, which eliminates the need for additional parts when switching between different container diameters. This feature, coupled with tool-less adjustments, significantly reduces downtime, making it an ideal solution for dynamic production environments. Capable of labeling speeds up to 240 bottles per minute, depending on container diameter and label size, this machine ensures high throughput and efficiency.

N.K Industries, a prominent manufacturer, supplier and exporter of pharmaceutical machinery, is based in Ahmedabad, Gujarat, India. Our reputation for engineering precision and reliability has established us as a leader in the field. Among our distinguished offerings is the Automatic Multi Head Vial Capping Machine, designed to meet the sophisticated needs of aseptic, injectable, and pharmaceutical plants. This advanced equipment is pivotal for ensuring the secure sealing of vials, which is crucial for maintaining the integrity and efficacy of pharmaceutical products.

The Significance of Vial Capping in Pharmaceutical Production

In the pharmaceutical industry, the capping of vials is a critical step in the production process. This process involves sealing vials containing injectable products to protect them from contamination and ensure their effectiveness. A hermetic seal is essential to maintain the drug's stability and prevent any external elements from compromising its quality. Given the importance of this task, the reliability and efficiency of the capping machine are paramount. The Automatic Multi Head Vial Capping Machine by N.K Industries is designed to provide just that—superior performance, precision, and efficiency.


Features and Configurations of the Multi Head Rotary Vial Capping Machine

Our range of Multi Head Rotary Vial Capping Machines is available in various configurations to suit different production needs. The models come in 4-head, 6-head, 8-head, and 12-head versions, each offering specific advantages based on the desired output and production scale. Depending on the configuration, these machines can deliver output rates ranging from 120 vials per minute to 400 vials per minute, ensuring that we can meet the diverse demands of our clients.

1. No Vial - No Capping System

One of the standout features of our Multi Head Rotary Vial Capping Machine is the “No Vial - No Capping” system. This system ensures that capping operations are performed only when a vial is present. The system uses advanced sensors and controls to detect the presence of vials and prevent the application of caps to empty positions. This not only reduces material waste but also enhances operational efficiency by eliminating the need for manual intervention and reducing the risk of errors.

2. Gradual Pressure Sealing (GPS) System

Another significant innovation is the Gradual Pressure Sealing (GPS) system. This technology applies sealing pressure gradually rather than abruptly, which helps in achieving a wrinkle-free and high-quality seal. The GPS system ensures that each cap is applied uniformly, resulting in a perfect hermetic seal that preserves the integrity of the drug. This advanced sealing mechanism is particularly beneficial for maintaining product quality and compliance with industry standards.

3. Compact and Modular Design

Our Multi Head Rotary Vial Capping Machines are designed with a compact and modular configuration. The modular design allows for flexibility and easy integration into existing production lines. This design also facilitates future upgrades and adjustments, making it easier to adapt the machine to evolving production requirements. The compact footprint of the machine ensures that it fits seamlessly into facilities with limited space, optimizing floor space utilization without compromising on performance.

4. CGMP Compliance

Compliance with Current Good Manufacturing Practice (CGMP) standards is essential in the pharmaceutical industry, and our Multi Head Rotary Vial Capping Machines are built to meet these rigorous standards. The machines are designed to minimize particle generation during the capping process, ensuring that the production environment remains clean and contamination-free. This compliance is crucial for maintaining the quality and safety of pharmaceutical products, and our machines are suitable for installation in conventional contamination-controlled environments and under isolators.

5. User-Friendly Operation

Ease of use is a key consideration in the design of our capping machines. The NKCS series features a user-friendly interface that simplifies operation and minimizes the need for extensive training. The intuitive controls and straightforward setup procedures ensure that operators can efficiently manage the machine with minimal effort. Additionally, the machine’s design focuses on reducing maintenance requirements, which helps in minimizing downtime and ensuring smooth, continuous operation.


 

Detailed Working Sequence of the Multi Head Rotary Vial Capping Machine

Understanding the working sequence of our Multi Head Rotary Vial Capping Machine provides insight into its operational efficiency and precision:

  1. Cap Loading: The process begins with loading sufficient caps into a vibratory bowl. The bowl continuously feeds the caps into the cap chute, ensuring a steady supply for the capping process.

  2. Vial Feeding: Vials are transported from the in-feed conveyor to the feed worm assembly via a slat conveyor. The feed worm creates spacing between vials before they are moved to the in-feed star wheel.

  3. Cap Transfer: As vials reach the in-feed star wheel, the vibratory bowl feeds caps into the chute. A NO-CAP sensor (Fiber Optic Sensor) monitors the cap supply. If the chute runs low on caps, the sensor signals the control panel, and the machine pauses until caps are replenished.

  4. Capping Process: The in-feed star wheel indexes each vial, transferring it to the main capping turret. The capping head and turret rotate clockwise, and the cam-operated capping head descends to apply the cap. The sealing chuck threads the cap and secures it onto the vial.

  5. Cap Removal: After the capping process is completed, the capping head rises, releasing the sealed vial. At the out-feed star plate, the capped vials are indexed further and transferred to the discharge end of the conveyor.

  6. Final Stage: The sealed vials move to the next on-line connected machine via the conveyor. A totalizer (counter) provides information on the total number of capped and sealed vials.


 

Manual Vial / Bottle Inspection Machines are economical series of vial/ bottle inspection machine. They are equipped with black & white board with proper illumination in order to check the impurities in filled vial/ bottles.Machine is designed in such a way that machine conveyor is made of three partition. Main middle portion of conveyor receive vials from upstream machine for inspection & two side conveyors taking out checked vials & transport them for auxiliary processing to downstream machine.

 

N.K. Industries, a distinguished manufacturer, supplier, and exporter based in Ahmedabad, Gujarat, India, proudly presents its series of Automatic Linear Vial Washing Machines (Tunnel Type). These machines are meticulously engineered for the thorough cleansing of injectable vials, reflecting extensive research and development in decontamination processes for containers used in injectable applications. Our series offers a range of models tailored to meet specific output requirements, with speeds ranging from 60 to 400 vials per minute.

Versatile and Efficient Washing

Our Automatic Linear Vial Washing Machine (Tunnel Type) is designed to accommodate a wide range of vial sizes, from 2ml to 100ml, with minimal format change requirements. This flexibility ensures that the machine can adapt to various production needs and vial specifications.

The washing process is comprehensive, featuring:

  • 8 Internal Washes: Utilizes a combination of compressed air, recirculated water, fresh DM (Deionized) water, and fresh WFI (Water for Injection) water to thoroughly clean the internal surfaces of the vials.
  • 2 External Washes: Employs recirculated water and fresh WFI water to effectively clean the external surfaces of the vials.

The washing sequence is customizable to meet specific customer requirements, providing a tailored cleaning solution for diverse applications.

Injectable Vial Filling & Stoppering Machine by N.K. Industries

N.K. Industries is a leading manufacturer, exporter, and supplier of a wide range of Injectable Vial Filling & Stoppering Machines, designed to meet the diverse needs of the pharmaceutical industry. These automatic machines are ideal for filling liquid into vials and simultaneously applying rubber stoppers, making them a crucial part of the complex injectable unit in pharmaceutical companies.

Our range of machines is available in 2-head, 4-head, 6-head, 8-head, and 12-head configurations, offering production speeds from 50 vials per minute to 200 vials per minute, depending on the fill volume. A standout feature of this machine is the innovative “No Vial - No Fill” system and “No Vial – No Stopper” system, ensuring high efficiency and minimal waste. The machine can also be customized with optional accessories like Laminar Air Flow, Toughened Glass Safety Cabinet, and Pre-Post Nitrogen Flushing Units for enhanced performance.


How Does the Injectable Vial Filling & Stoppering Machine Work?

The working process of the Injectable Vial Filling & Stoppering Machine is precise and reliable. Here’s a step-by-step overview:

  1. Feeding Vials: Sterilized dry vials are fed via an unscrambler onto a AISI 304 Made Slat Conveyor Belt at a controlled speed, ensuring correct placement under the filling unit.

  2. Filling Process: The filling unit consists of syringes and nozzles. The syringes, available in stainless steel 316 (SS316) or glass (customer’s choice), are driven by a gear system. The fill volume can be adjusted by modifying the stroke length of the piston. A Star Wheel holds the vials during the filling process, while a sensor ensures “No Vial - No Fill” operation.

  3. Liquid Transfer: Liquid is transferred through a silicon transparent pipe, with the nozzle moving up and down, controlled by a cam mechanism. Once the vial is positioned, the filling begins, and after completion, the star wheel moves the vials to the stoppering unit.

  4. Stoppering Process: The sterilized rubber stoppers are fed via a Vibrator Bowl to the chute. As the star wheel moves the vials, the stopper is automatically picked up and pressed onto the vial by a spring-loaded pressing roller. The vials then move to the conveyor for the next sealing operation.

N.K Industries ‘s ISO  class 5  continuous  Sterilization Tunnel  is  basically  a  fully  automated  system  which  utilizes  dry  heat  by  means  of  forced  convection  of  filtered  air  through  high  efficiency  particulate  air  filter  to  achieve  sterilization  of  washed  empty  pharmaceutical  glasswares  used  for  parenterals  product  packaging. N.K Industries ‘s  continuous  dry  heat  Sterilization Tunnel  ensures  glassware  is  exposed  to  depyrogenation  temperature  for  time  required  for  the  necessary  reduction  in  endotoxins  which  at  bare  minimun  is  >  log  3 at  rated  output.

N.K Industries continuous  dry  heat  Sterilization Tunnel  can  be  used  as  a  standalone  unit  or  can  be  supplied  configured  for  easy  integration  with washing machine  at  its  upstream  side  and  filling  -  sealing  machine  at  its downstream  side  thereby  forming  high  speed  -  high  yield  parenteral  product  packaging  line. 

The forced conventional dry Sterilization Tunnel consists of Drying Zone to evaporate the wash water from glassware. The sterilizing Zone sterilizes the glassware at 300 0c (apprx). And the third section consists of cooling and sterilizing zone to restore the glassware temperature to ambient.

The Carton Packaging conveyor belt receive container/ products from the primary upstream packing line like after inspection/ labelling/ blister/ strip machine. After that operator in turn pickup these bottles/products and putting them manual in Carton and complete the secondary packaging.

 

Carton Packing conveyor belt consists of table top & 9" wide PVC coated canvas endless belt at the centre. The table top is covered with AISI 304 Sheet & width of the table is 33". It is mounted on AISI 304 structure. It is driven by induction motor coupled with suitable reduction gear box. The complete drive mechanism is enclosed in an elegant cabinet. The speed of the belt is 30 ft to 40 ft/min.

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